Herpes simplex - Herpes Simpleks
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Herpes simpleks ing lambe.
Herpes Simpleks (Herpes simplex) ― Infeksi herpes simplex ing driji luwih umum ing bocah cilik tinimbang ing wong diwasa.
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ReferencesInfeksi HSV-1 berkembang liwat infeksi utama ing sel epitel, banjur mlebu fase laten, utamané ing neuron, lan bisa reaktif maneh. HSV-1 umume nyebabake erupsi vesikular awal lan lesi, utamane ing tutuk lan mukosa genital. Manifestasi kasebut kalebu saka herpes orolabial nganti macem‑macem kondisi kaya folliculitis herpetic, infeksi kulit, keterlibatan okular, lan kasus abot kaya herpes encephalitis. Terapi antivirus mbantu ngatasi infeksi HSV.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) minangka infèksi sing nyebar, ngaruhi udakara 22 % wong diwasa umur 12 taun lan luwih, kira‑kira 45 yuta wong diwasa ing Amerika Serikat. Nalika HSV-1 biasane nyebabake lara lisan, uga bisa nyebabake lesi genital. Nanging, nalika pasien ngalami lesi genital, HSV-2 biasane dadi perhatian utama. Gejala infèksi HSV-2 asring samar, kayata gatel lan iritasi alat kelamin, sing bisa nundha diagnosis lan perawatan. Penundaan iki bisa nambah risiko transmisi luwih lanjut marang wong sing durung kena infèksi.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) umume nyebabake infeksi kaya herpes genital lan lara kadhemen ing remaja lan wong diwasa. Nalika HSV nginfeksi bayi ing umur 4‑6 minggu pisanan urip, bisa nyebabake penyakit sing abot kanthi akibat sing serius. Diagnosa cepet infeksi HSV neonatal penting banget kanggo nyegah penyakit kasebut dadi luwih parah, lan nyegah komplikasi neurologis (malah mati).
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex iku infeksi sing umum banget lan bisa ditularake saka wanita ngandhut menyang bayi. Virus iki bisa nyebabake masalah kesehatan sing serius utawa malah nyebabake pati ing bayi anyar. Sanajan arang banget kedadeyan nalika kehamilan, infeksi iki asring muncul nalika proses persalinan. Resiko paling dhuwur yen ibune kena infeksi ing tahap pungkasan kehamilan. Nanging, risiko iki bisa dikurangi kanthi nggunakake obat antivirus utawa milih kategori C ing kahanan tartamtu.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) jinis 1 lan 2 nginfeksi akèh wong ing saindenging jagad. Biasane, virus tetep sepi ing sel saraf sawisé nginfeksi kulit, nanging bisa diaktifaké maneh mengko, nyebabaké lara kadhemen. Kadhangkala, virus iki bisa nyebabaké masalah abot kaya infeksi mata, inflamasi otak, utawa kahanan sing mbebayani ing bayi lan wong kanthi sistem kekebalan sing lemah. Sanajan obat‑obatan saiki mbantu ngontrol infeksi, risiko resistensi obat lan efek samping tetep dadi kuwatir. Kita butuh obat anyar sing luwih tepat kanggo target virus.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Ana rong jinis virus herpes simpleks (herpes simplex), yaiku jinis 1 (HSV-1) lan jinis 2 (HSV-2). HSV-1 luwih umum nyebabake infeksi ing sakubengé tutuk, dene HSV-2 luwih umum nyebabake infeksi genital. Virus iki ditularake kanthi kontak langsung karo wong sing kena infeksi. Herpes genital diklasifikasikaké minangka infeksi seksual lan bisa nyebar menyang bayi nalika nglairake. Sawise infeksi, virus kasebut diangkut liwat saraf sensori menyang badan sel saraf, ing ngendi virus manggon seumur hidup. Faktor sing nyebabake kambuh antara liya: penurunan fungsi kekebalan, stres, lan cahya srengenge.
Umume kasus, obat antivirus mung dijupuk nalika gejala abot. Pangobatan antivirus saben dina bisa diwènèhaké marang wong sing kena infeksi kanthi frekuensi dhuwur. Ora ana vaksin sing kasedhiya, lan vaksin shingles ora nyegah herpes simplex. Pangobatan nganggo obat antivirus kayata asiklovir utawa valaciclovir bisa nyuda keparahan gejala.
Tingkat HSV-1 utawa HSV-2 ing saindenging jagad antara 60 % nganti 95 % ing wong diwasa. HSV-1 biasane kena infeksi nalika isih cilik. Kira‑kira 536 yuta wong ing saindenging jagad (16 % saka populasi) kena infeksi HSV-2 ing taun 2003, kanthi prevalensi luwih dhuwur ing wanita lan ing negara berkembang. Umume wong sing duwe HSV-2 ora ngerti yen dheweke kena infeksi.
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